General description

An antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (K_i = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt′s lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, however it inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.

An antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes. Competitively inhibits hFKBP12 (K_i = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt's lymphoma cells, and other cell types. A 100 mg/ml solution of Cycloheximide (Cat. No. 239765) in DMSO (sterile-filtered) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Christner, C., et al. 1999. J. Med. Chem.42, 3615.Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys.334, 175.Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.Waring, P. 1990. J. Biol. Chem.265, 14476.Obrig, T.G., et al. 1971. J. Biol. Chem.246, 174.Pestka, S. 1971. Annu. Rev. Microbiol.25, 487.

Packaging

1, 5 g in Glass bottle

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)